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Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding. Such decrease, possibly due to interference with B 12 absorption from the B 12-intrinsic factor complex, is, however, very rarely associated with anemia and appears to be rapidly reversible with discontinuation of metformin hydrochloride tablets or Vitamin B 12 supplementation.

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Evidence of persistent cognitive impairment after resolution of overt hepatic encephalopathy [published online ahead of print October 15, 2010]. There are no adequate and well-controlled studies in pregnant women.

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It also found that the fresh garlic could be a suitable alternative to drugs for serious systemic infections in patients with severe immune suppression.

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